Faster DNA Analysis at Room Temperature
DNA microarrays are one of the most powerful tools in molecular biology today. The devices, which can be used to probe biological samples and detect particular genes or genetic sequences, are employed in everything from forensic analysis to disease detection to drug development.
Now Paul Li and colleagues at Simon Fraser University in Burnaby, Canada have combined DNA microarrays with microfluidic devices, which are used for the precise control of liquids at the nanoscale. In an upcoming issue of the journal Biomicrofluidics, which is published by the American Institute of Physics (AIP), Li and his colleagues describe how the first combined device can be used for probing and detecting DNA.
The key to Li’s result: gold nanoparticles. Suspended in liquid and mixed with DNA, the nanometer-scale spheres of gold act as mini magnets that adhere to each of the DNA’s twin strands. When the DNA is heated, the two strands separate, and the gold nanoparticles keep them apart, which allows the single strands to be probed with other pieces of DNA that are engineered to recognize particular sequences.
Li, whose work is funded by the Natural Sciences and Engineering Research Council of Canada, is applying for a patent for his technique. He sees a host of benefits from the combination of DNA microarrays and microfluidics.
“It’s faster and requires a relatively small sample,” he says, adding in his paper that “the whole procedure is accomplished at room temperature in an hour and apparatus for high temperature… is not required”
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This article is about a machine that has been realised which allows genes to be examinaned easier and faster. This machine also allows you to use less information to get the correct outcome and it can be accomplished at room temperature so a high temerature is not needed.
I thoughht this article was a good sence of knowlege by letting us know a variety of things. I personally think it was kinda interesting but coul of been more shorter than it is because of the useless info it gives us in some parts.I now know that microrays are the most powerful tool in biology. An now i also know what their use is in todays world.
DNA microarrays are the most important tools in biology. Paul Li and colleagues at Simon Fraser University in Burnaby, Canada, combined DNA microarrays with microfluidic devices. This is used for the precise control of liquids at the nanoscale. This machine is now faster and you can use less information, because it is at room temp. It still does the same thing through.
This article is very helpful. It states that a machine is about to probe your DNA in room temperature. When heated the DNA is sperated and harder to work with. With this machine you are able to use less information but still get the sample. The DNA microarrays isone of the most powerful tools in molecular biology today. This article was really interesting.
1. DNA microarrays are one of the most powerful tools in molecular biology today.
2. P.L. & S.F. combined DNA microarrays with microfluidic devices.
3. The result: an easy way to detect dna.
4. Can use very small samples.
5. Can do this at room temperatture!
1. P.L. & S.F. combined DNA microarrays with microfluidic devices.
2. The result: an easy way to detect dna.
3 can use extremaly small samples.
4 DNA microarrays are one of the most powerful tools in molecular biology today.
5 room temp.
Paul Li and colleagues at Simon Fraser University in Burnaby, Canada have combined DNA microarrays with microfluidic devices. In an upcoming issue of the journal Biomicrofluidics it tells how the first combined device can be used for probing and detecting DNA. Suspended in liquid and mixed with DNA, the nanometer-scale spheres of gold act as mini magnets that adhere to each of the DNA’s twin strands. When the DNA is heated, the two strands separate, and the gold nanoparticles keep them apart, this lets the single strands to be connected with other pieces of DNA that are engineered to recognize particular sequences.
1. DNA microarrays are one of the most powerful tools in molecular biology today.
2. The key to Li’s result: gold nanoparticles.
3. He sees a host of benefits from the combination of DNA microarrays and microfluidics.
4. The procedure is fast and uses a small sample.
5. everything can be done in an hour and in room temp.