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New Lab Evidence Suggests Preventive Effect Of Herbal Supplement In Prostate Cancer

DHEA is a natural circulating hormone and the body’s production of it decreases with age. Men take DHEA as an over-the-counter supplement because it has been suggested that DHEA can reverse aging or have anabolic effects since it can be metabolized in the body to androgens. Increased consumption of dietary isoflavones is associated with a decreased risk of prostate cancer.

Red clover (Trifolium pretense) is one source of isoflavones. Both supplements may have hormonal effects in the prostate and little is known about the safety of these supplements.

In a recent report in Cancer Prevention Research, a journal of the American Association for Cancer Research, researchers report that DHEA levels can be manipulated in cells in the laboratory to understand its effects.

Julia Arnold, Ph.D., a staff scientist at the National Center for Complementary and Alternative Medicine (NCCAM) at the National Institutes of Health, said more research is necessary in an environment where men and women concerned about health problems tend to self-prescribe based on information they find on the Internet.

Towards this end, the NCCAM laboratory is studying signaling between human prostate cancer cells and their supporting stromal cells as they grow together in laboratory culture. “DHEA effects in the prostate tissues may depend on how these two cells types ‘talk to each other’ and further, it may be potentially harmful in tissues containing inflammation or with early cancer lesions because the cells can induce DHEA to become more androgenic,” said Arnold.

Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells and prostate specific antigen protein secretion two to four-fold and gene expression up to 50-fold in the cancer cells. When these cell cultures were treated with red clover isoflavones, the androgenic effects of DHEA were reversed.

“Something is happening in the prostate tissue microenvironment that is illustrating a potential cancer prevention effect from this supplement,” said Arnold.

Red clover isoflavones may modify androgenic effects in the prostate but much more work in the laboratory and clinic is needed to validate these effects.

This sort of laboratory manipulation will allow scientists to understand the basic prostate biology as well as learn cellular and molecular mechanisms of over-the-counter supplements and other botanical or herbal agents. Arnold said NCCAM will continue to study DHEA with other supplements to determine any cancer preventive effects.

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33 Comments for “New Lab Evidence Suggests Preventive Effect Of Herbal Supplement In Prostate Cancer”

  1. Tonya Heathington

    This article is about preventive effect of herbal supplement in prostate cancer.
    1. A journal of the American Association for Cancer Research report say that manipulated in cells in the lab to unnderstand it’s effects.
    2. The NCCAM is studying between signaling between human prostate cancer cells their supporting stromal cells as they together in the labortory culture.
    3. Red Clover is a souce of isoflavones.
    4.DHEA a natural circulating hormones the body’s production of it decreases with age.
    5. Scientist at the National Center for Complementary and Alternative Medicine at the National Institutes of Health, said more research is necessary in an environment where men and women worried about health problems tend to self-prescribe based on information they find on the Internet.

  2. DHEA is a natural hormone of the body. Red clover is a source of isoflavones. red clover isoflavones modifies androgenic effects.

  3. Caroline Whorton

    DHEA is a natural hormone.
    Red clover is one source of isoflavones.
    Some men use DHEA because it can reverse aging.
    In an environment many men and women are concered about health problems.
    DHEA effects in the prostate tissues.

  4. Elizabeth Sanders 1st period

    Article Summary for August 24, 2009

    1. Cell cultures treated with red clover isoflavones reveresd the affects of DHEA.
    2. Red Clover is one source of isoflavones.
    3. Comsumption of dietary isoflavones is associated with a decreased risk of prostate cancer.
    4. Researches report that DHEA levels can be manipulated in cells in the lab to understand its affects.
    5. DHEA is a natural circulating hormone and the body’s production of it decreases with age.

  5. Article Summary for August 24, 09

    1.DHEA is a natural hormone.

    2.Some men use DHEA because it can reverse aging.

    3.Red clover is one source of isoflavones.

    4.Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells.

    5.DHEA effects in the prostate tissues

  6. 1.Red clover is on source of isoflavones.
    2.DHEA is a natural home.
    3.DHEA effects the prostate hormone.
    4.Males take PHEA an an over-the-counter supplyment because it has been suggested.
    5.The NCCAM is studying between signaling between human prostate cancer cells.

  7. Ruhi singh 2nd period

    1.DHEA is a natural hormone.
    2.Red clover is one source of isoflavones
    3.Red clover isoflavones may modify androgenic efects in the prostate.
    4.Men take DHEA so they can reverse aging.
    5. NCCAM will study DHEA to determine any cancer preventive effects.

  8. takara alexander 5th pd

    1.DHEA is a natural hormone
    2.Red clovers is on source of isoflavones
    3.Red clover isoflavones modifies androgenic effects in the prostate
    4.Dietary isoflavones may have a increase of cancer
    5.NCCAM will study DHEA to determine any cancer preventine effects

  9. 1.DHEA is natural hormone.
    2.Red clovers is on the soures of isoflavones
    3.Red clover insoflavone modifies androgenic effects in the prostate.
    4.Dietetary isoflavones may have a increase of canser.
    5.NCCAM will study DHEA to determine any canser efects.

  10. 1.DEAH is a natural hormone.
    2.Red clovers is a sourse of isoflavones.
    3.NCCAM will study DHEA is to determine any caser effects.
    4.Red clover insoflavone modifies andogenic effects in the prostrate.
    5.Dietetary isflavones may have increased of canser.

  11. Kathryn Wilson 4th

    1. DHEA is a natural hormone and the body’s production of it decreases with age.
    2. DHEA can reverse aging or have anabolic effects since it can be metabolized in the body to androgens.
    3.Red clover is a source of isoflavones.
    4.DHEA combining with growth factor beta-1 increased testosterone production in the stromal cells.
    5.DHEA effects in the prostate tissues.

  12. Pamela Hussey-6th Period

    1. DHEA- A natural circulating hormone.
    2. DHEA is the body’s production of it decreases with age.
    3. Men take it as a over the counter supplement because it has been suggested that it can reverse aging.
    4. Red clover is one source of isoflavones.
    5. DHEA effects in the prostate tissues.

  13. natalie seavers 6th

    DHEA is one of the natraul hormones

    DHEA can reverse aging

    red clover isoflavones may modify androgenic efects in the prostate

    combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells

    DHEA effects in the prostate tissues.

  14. Zach Bennett 1st period

    DHEA is one of a matural hormone
    Red clover is one source of isoflavones.
    Red clover isoflavones may modify androgenic effects in the prostate
    DHEA effects in the prostate tissues may depend on 2 types of cells
    Men take DHEA as an over-the-counter supplement

  15. Taylor Brown (period)5

    1.A plant can be the solution to some health problems
    2.The plant is a good source of isoflavones
    3.May have an effect on cancer cells
    4.It is said to reverse aging
    5.DHEA is a natural hormone

  16. 1. DHEA- A natural circulating hormone that the body decreases production of with age.
    2. Men take it as a over the counter supplement because it has been suggested that it can reverse aging
    3. DHEA may have anabolic effects since it can be metabolized in the body to androgens.
    4. Red clover is one source of isoflavones.
    5. DHEA effects in the prostate tissues and may have anti cancer effects with more study.

  17. This article is about new lab evidence that suggests the preventive effect of an herbal supplement in prostate cancer. DHEA has been used by men because it has been known to reverse aging or have anabolic effects because it can be metabolized in the being to androgens. Red clover contains isoflavones. Researchers say that DHEA levels will possibly be handled in cells in the lab to understand its effects. DHEA effects in prostate tissues might be harmful in other tissues. More research is needed to understand the biology of the prostate and the effect of supplements in preventing prostate cancer.

  18. Ryan Chamberlain 1st Period Science :D

    Article Summary:

    1.DHEA is a natural hormone.

    2.It has been suggested that DHEA can reverse aging.

    3.Red clover is one source of isoflavones.

    4.DHEA is an over-the-counter supplement.

    5.Red clover isoflavones may modify androgenic effects in the prostate.

  19. 1. DHEA is a natural hormone and the body’s production, it decreases with age.
    2. Boys take DHEA as an supplement because it has been suggested that DHEA can reverse aging.
    3. DHEA is associated with a decreased risk of prostate cancer.
    4. The NCCAM will study DHEA is to determine any cacer effects.
    5. DHEA is a red clover.

  20. Tara Harville (per.1)

    1. Dhea is a natural circulating hormone and the body’s production of it decreases with age.
    2. Dhea is an over the counter daily supplement.
    3. Laboratories are studying signals between human prostate cancer cells and their supporting stromal cells as they grow together in laboratory culture.
    4. Dhea can reverse aging.
    5. Red clover isoflavones may modify androgenic effects in the prostate but much more work in the laboratory and clinic is needed to validate these effects.

  21. I learned that DHEA is a hormone and it manufactures in the body. Some men take it because it may reverse aging. DHEA effects in the prostate gland. One source for isoflavones is red clover. Red clover isoflavones may correct androgenic effect in the prostate gland.

  22. DHEA is one of a matural hormone
    Red clover is one source of isoflavones.
    Red clover isoflavones may modify androgenic effects in the prostate
    DHEA effects in the prostate tissues may depend on 2 types of cells
    Men take DHEA as an over-the-counter supplement

  23. Madeline Holifield 4th period science

    1.Men take DHEA as an over-the-counter supplement because it has been suggested that DHEA can reverse aging or have anabolic effects since it can be metabolized in the body to androgens.
    2.Red clover isoflavones may modify androgenic effects in the prostate.
    3.DHEA effects in prostate tissues but might be harmful in other tissues.
    4.DHEA is a natural hormone and the body’s production of it decreases with age.
    5.This sort of laboratory manipulation will allow scientists to understand the basic prostate biology as well as learn cellular and molecular mechanisms of over-the-counter supplements and other botanical or herbal agents.

  24. Savannah Meagher 2nd

    1. DHEA is a natural circulating hormone and the bodies production of it decreases with age.
    2.Red Clover ( Trifolium pretense) is one source of isoflavones.
    3.Both supplements may have hormonal effect in the prostate and little is known about the saftey of these supplements.
    4.Somethingis happening in the prostate tissue microenviorment that is illistrated as a potential cancer provention effect from this supplement.
    5. Red clover isoflavones may modify androgenic effects in the prostate but much more work in the labortory and clinic is needed to vaildate these effects.

  25. Elizabeth Sanders 1st period

    Article Summary for January 18, 2010

    1. Dhea is over the counter supplement.
    2. Dhea is a red like clover.
    3. Dhea is a natural hormone.
    4. Efects the prostate hormone.
    5. Some men use Dhea because it can reduce aging.

  26. Lena Carter 1st period

    Articke Summary
    1.DHEA is a natural circulating hormone.
    2.Because DHEA can revearse aging some men use it.
    3. Red clover is one source of isoflavones.
    4. Combining DHEA with transforming growth factor beta-1 increased testosterone production in the stromal cells.
    5. Men and women concerned about health problems tend to self-prescribe based on information they find on the Internet.

  27. 1. scientists are trying to help people with prostate cancer
    2.you can get prostate cancer different ways
    3Red clover is one source of isoflavone
    4.peostate cancer is a dangerous thing
    5.dhea is a diesese

  28. Maysie Spears 4th period

    1. DHEA is a natural circulating hormone.
    2. Men take DHEA because it is an over-the-counter drug used to reverse aging.
    3. In a recent report in the Cancer Prevention Research, figured out that DHEA levels can be manipulated in cells.
    4. Red clovers is a source for isoflavones.
    5. DHEA effects in the prostrate tissues.

  29. Kelsey schronce 5th perod

    1. Cell cultures treated with red clover isoflavones reveresd the affects of DHEA.
    2. Red Clover is one source of isoflavones.
    3. Comsumption of dietary isoflavones is associated with a decreased risk of prostate cancer.
    4. Researches report that DHEA levels can be manipulated in cells in the lab to understand its affects.
    5. DHEA is a natural circulating hormone and the body’s production of it decreases with age.

  30. max Stephenson 2nd

    1. DHEA- A natural circulating hormone that the body decreases production of with age.
    2. Men take it as a over the counter supplement because it has been suggested that it can reverse aging
    3. DHEA may have anabolic effects since it can be metabolized in the body to androgens.
    4. Red clover is one source of isoflavones.
    5. DHEA effects in the prostate tissues and may have anti cancer effects with more study.

  31. Robert McClintock 2nd

    1. DHEA is a natural circulating hormone.

    2. Because it is proven to DHEA can reverse aging men would use it.

    3. The increase consumption of dietary oflavones is associated with a decreased risk of prostate cancer.

    4.The Red clover (Trifolium pretense) is one source of isoflavones.

    5. Both of the supplements may have hormonal effects in the prostate and little is known about the safetys of these supplements.

  32. Chase R. Massey

    1. Red clovers are a source of isoflavones.
    2. DHEA is a natural circulating hormone.
    3. DHEA effects in the prostrate tissues.
    4. Peostate cancer is a dangerous disease.
    5. Scientists are trying to help peope with peostate cancer.

  33. Jenna Marshall 1st period

    ~DHEA is a natural hormone and the body’s production of it decreases with age.

    ~Men take DHEA as an over-the-counter supplement.

    ~Red clover isoflavones may change effects in the prostate but much more work in the laboratory and clinic is needed to validate these effects.

    ~This laboratory manipulation will allow scientists to understand the basic prostate biology.

    ~NCCAM will continue to study DHEA.

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